Three extracts were prepared from the leaves of accacia. Studies about antimutagenic activities of fermented foods miso, pito, nai ge da have shown that microorganisms isolated from these foods have higher antimutagenic activities. Chemical and physical properties of chlorophyll need to be determined in order to reduce its loss during food processing and storage. The results indicate that investigating antioxidant activity and the number of antioxidant compounds in plant extracts could be a viable option in searching for antimutagenic compounds in plants.
To the best of our knowledge, this is the first report on the antimutagenic activity of r. Studies on the antimutagenic activity of ascorbic acid in. Full text get a printable copy pdf file of the complete article 923k, or click on a page image below to browse page by page. Evaluation of antioxidant activities and antimutagenicity. The study indicated that the antimutagenic activity of quercetin was not solely accountable by its antioxidant nature. Increase of single break repair by rejoining and induction of genes related to base and nucleotide excision. Evaluation of the mutagenic andor antimutagenic activity. The possibility that ascorbic acid, as a nucleophile, may in hibit mutagenicity induced by electrophilic metabolites of nnitroso compounds was exam. To identify the antimutagenic component, the antimutagenic activity against mnu was compared among aqueous and methanol extracts fig. This present research highlight the phytochemical profile, the antioxidant, the antimicrobial, the antimutagenic and the antiproliferative activities of an essential oil extracted from corchorus olitorius l. Antimutagenic activity of spearmint yu 2004 environmental and. The antimutagenic effect of compounds can be evaluated on the basis of their ability to inhibit mutagens mutagenicity 4143. Graduate thesis or dissertation antimutagenic potency of wheat grain and berry extracts in vitro and anticarcinogenicity of wheat grain in vivo public deposited.
Antimutagenic activity of the dte was carried out in two different strains of salmonella typhimurium. The correlation between antimutagenic activity and total. List of 120 plant species that were extracted with methanol to determine quantitative antioxidant activity in order to select 31. Antioxidant, antimutagenic and cytotoxic properties of. The correlation between antimutagenic activity and total phenolic. The mutagenic, antimutagenic and antioxidant properties of. New fluphenazine analogue with antimutagenic and antimultidrug resistance activitydegradation profile and stabilityindicating method agnieszka sobczak 0 1 2 artur tezyk 0 1 2 joanna szyndlarewicz 0 1 2 jan ziarniak 0 1 2 piotr swiatek 0 1 2 wieslaw malinka 0 1 2 0 department of chemistry of drugs, wroclaw medical university, 211 borowska str. Antioxidant and antimutagenic activities of different. There was a direct correlation between the presence of antioxidant activity and antimutagenic activity of the plant extracts. It is also used as a foodcoloring agent and known as natural green 3, and it has the e number e141. Darjeeling tea, a most popular variety of black tea, though consumed by the people in different parts of world but its beneficial health effects have not been investigated in details. Antimutagenic activity was evaluated using micronucleus test in mice. Antimutagenic activity of vinoserae extract in ames test without metabolic activation, strain ta102. Pdf methanolic extracts of acorus calamus rhizome, hemidesmus indicus stem, holarrhena antidysenterica bark and plumbago.
Antimutagenic and mutagenic potentials of chinese radish. In addition, the antimutagenic activity toward aflatoxin b1 may be partly due to the inhibition of enzymes necessary for activation of this mutagen. Antimutagenic activity, % concentration, mgplate leaves rhizomes 8 9 28 28 63 75 0 10 20 30 40 50 60 70 80 90 0. As part of a study aimed at developing new pharmaceutical products from natural resources, the purpose of this research was twofold. Table 2 shows the differential antimutagenic activity of honey against uv and gamma induced mutagenesis in e. In this study, antimutagenic activity of an ethanol extract of rhaphidophora pinnata leaves was evaluated by. The results showed that a significant antimutagenic effect of the extract was detected with both oxidative mutagens used figure 1. Antimutagenic and antioxidantprooxidant activity of. Fenugreek alkaloids was found to be more effective than parsley oil in this respect. However, further studies to define the relationship between exposure to.
The pdf file you selected should load here if your web browser has a pdf reader plugin installed for example, a recent version of adobe acrobat reader if you would like more information about how to print, save, and work with pdfs, highwire press provides a helpful frequently asked questions about pdfs alternatively, you can download the pdf file directly to your computer, from where it. Marked antimutagenic potential of aqueous green tea. Found to perform antimutagenic activity through the increase of ogg1 expression, which is an enzyme responsible to remove 8oxoguanine a mutagenic product created after cells exposure to oxidative stress. Antimutagenic components in spatholobus suberectus dunn.
Firdous, ramnath viswanathan and ramadasan kuttan affiliation. Antiformation and antimutagenic activities of extracts. In vitro antioxidant activity of quercetin was better than ascorbic acid in all the test systems used. Many substances with antimutagenic activity have been found by several investigators soudamini et al. Pdf evaluation of the antimutagenic and anticarcinogenic. Antimutagenic activities of some foods, journal of the. Antibacterial and antimutagenic activities of novel zerumbone analogues s. The antimutagenic activity of both the extracts was evaluated against sodium azide, 4nitroophenylenediamine and 2aminofluorene mutagens in ta98 and ta. In this study, the antimutagenic and anticancer effect of darjeeling tea extract dte has been evaluated. Medical university in partial fulfillment of the regulations for the award of the degree of m. Antioxidant and antimutagenic activity of curcuma caesia roxb. Antimutagenic activity an overview sciencedirect topics. Antimutagenic and anticancer activity of darjeeling tea in. This study investigates for the first time the antioxidant, mutagenic and antimutagenic activity of an ethanol extract of h.
New fluphenazine analogue with antimutagenic and anti. The fluorine substitution changed the antimutagenic signature of bichalcophenes. This article is from annals of clinical microbiology and antimicrobials, volume 10. Pdf antioxidant, mutagenic, and antimutagenic activity. The present study was designed to detect the mutagenic effects of vincristine vcr anticancer drug and antimutagenic effects of some. Antimutagenic activity of lutein an oxycarotenoid present. Antimutagenic activity of plant extracts is important in the discovery of new, effective cancer preventing agents. Suppression of error prone pathway is responsible for. Detection of the antimutagenic activity of the vinoserae extract was carried out using the ames test with salmonella typhimurium his. Acorus calamus, antimutagenic activity, hemidesmus indicus, holarrhena antidysenterica, medicinal plants. Hydroxyl radicalscavenging activity of the flavonoids derived from s. The antimutagenic activity has been assayed in the antimutagenic and antioxidant activity of the extract from belamcanda chinensis l. Antimutagenic and dna damage protective activities of a. Abstract the antimutagenic activity of spearmint mentha spicata, a popular food flavoring agent, was studied in the salmonella assay.
Mutageneic and antimutagenic effects of some plant. Antioxidant, mutagenic, and antimutagenic activity of frozen fruits article pdf available in journal of medicinal food 111. Antimutagenic activity of extracts of natural substances in the. The over all antimutagenic potential of above four extracts was found to be in order of a. Antimutagenic activity of lutein an oxycarotenoid present in the macula and its inhibition of cytochrome p 450 enzymes in vitro volume. There are different classes of secondary metabolites present in the plants exhibiting antimutagenic activities. Antimutagenic activity of alkylresorcinols from cereal. All mutagens have characteristic mutational signatures with some. The antimutagenic activity showed that all of the extracts exhibited strong inhibition especially the ethanol extract of p. Request pdf antimutagenic activity of turmeric extract beverages objective. The mutagenic and antimutagenic activities of hexane, chloroform, ethyl acetate and methanol extracts from leaves of myrtus communis, were investigated by. There is increasing evidence that cancer and other mutationrelated diseases can be prevented by intake of dna protective agents. Graduate thesis or dissertation antimutagenic potency of.
Review study on potential activity of piper betle abstract piper betle is glorified as evergreen and perennial plant that god designed and have given the shape of his own heart. Antimutagenic activity of turmeric extract beverages request pdf. The alta has shown potent antioxidant activity with ec50 of 2. The antioxidant effects of turmeric oil and its fractions may provide an explanation for their antimutagenic action. Dc article pdf available in acta poloniae pharmaceutica 633. T14099 branches mexico antimutagenic activity hot h2o ext not stated 3. Rhaphidophora pinnata is suggested to prevent or treat cancer of genetic mutations. The antimutagenic activity of two plants maytenus ilicifolia and peltastes peltatus, both rich in compounds of the flavonoid and tannin groups and frequently.
Pdf antimutagenic activity of olive leaf aqueous extract by ames. The antimutagenic activities of the cell bodies of several lab isolated from kimchi were studied using the ames test and the sos chromo test son et al. Antimutagenic and anticarcinogenic activity of tea polyphenols. In fact, the tested extracts are the complex mixtures of several compounds, particularly phenolic compounds which have diverse chemical structures that determine various properties. As many mutations can cause cancer, mutagens are therefore also likely to be carcinogens, although not always necessarily so. These flavonoids have been reported to have anticancer activity 3639, and the antimutagenic activity was considered to contribute to their anticancer activity. Apparatus uv and ir spectra were measured with varian cary 100 conc andshimadzu8300ftir,respectively. Isolation and antimutagenic activity of some flavanone. If the inline pdf is not rendering correctly, you can download the pdf file here. Chemotherapeutic drugs have high toxicity associated with undesirable sideeffects. In genetics, a mutagen is a physical or chemical agent that changes the genetic material, usually dna, of an organism and thus increases the frequency of mutations above the natural background level. The maximal decrease in the revertant numbers was found when the figure 1. Antimutagenic activity of alkylresorcinols from cereal grains the effect was the strongest in the case of indirectacting mutagens, benzo a pyrene and 2aminofluorene. In addition, antimutagenic and antigenotoxic effects evaluated by micronucleus and the comet test showed that extracts of shiitake have a antigenotoxic and antimutagenic activity 52 in vivo 53.
The antimutagenic activity of the three compounds were determined in the ames test using salmonella typhimurium ta98, ta100 and ta102. Pdf abstract medicinal plants are an important source of substances which are claimed to induce antiinflammatory and antioxidant effects. File scanned at 300 ppi monochrome using capture perfect 3. Tea catechins and crude extracts, however, have some beneficial effects on human health, such as suppression of a rise in blood pressure. The study reveals the strong antioxidant and antimutagenic activity of r. Biological activities for extracts of clavillia mirabilis. Amala cancer research centre, amala nagar, thrissur, kerala680 555, india. However, in vitro free radical scavenging activity of quercetin correlated well with the antimutagenic activity. Antimutagenic and antioxidant activity of the extract from belamcanda chinensis l. Some of these compounds could be selected for further anticancer studies. It is used in the popular medicine for the syphilis treatment, diaphoresis, inflammations etc. The antimutagenic activity was congruent with a high antioxidant activity that could promote the dna repair system. In the case of directacting mutagens, daunorubicin and methyl methanesulfonate, the diminution of the mutagenic activity by the alkylresorcinols was smaller but still noticeable. Evaluation of antimutagenic activity and mechanisms of action of.
Pdf antimutagenic activity of methanolic extracts of four ayurvedic. Antioxidant and antimutagenic activities of bark extract. Dorota woeniaka, jan oszmiaskib and adam matkowskia adepartment of pharmaceutical biology and botany, medical university in wroc. The antioxidant activity of the three compounds were determined by the quantitative 2,2diphenyl1picrylhydrazyl dpph free radical scavenging method. Honey of either brand was not found to affect the background rif r frequency and hence considered to be nonmutagenic in this assay system. Dose dependent antimutagenic activity of the extracts is also evident from linear regression analysis of the data. The importance of free radicals and catalytic metal ions in human diseases. Our study is based on 3 assays that are widely used to evaluate. The correlation between antimutagenic activity and total phenolic content of extracts of 31 plant species with high. A comparison of the antimutagenic potential of green, black and decaffeinated teas.
Antimutagenic activity of methanolic extracts of four. Pdf the incidence of colorectal cancer is growing worldwide. The identification of antimutagenic agents present in plants presents an effective strategy to inhibit pathogenic processes resulting from exposure to. Pdf invitro antioxidant, antimutagenic and cancer cell. The heart shaped of piper betle leaves are initiate in ancient sanskrit texts, include. In vitro antimutagenic activity of eclipta alba using ames test dissertation submitted to the tamiladu dr. Molecules free fulltext antioxidant and antimutagenic. Antibacterial and antimutagenic activities of novel. Pdf evaluation of the antimutagenic activity and mode of. In vitro antioxidant and antimutagenic activities of different solvent. Supporting information structures and antimutagenic. Antimutagenic properties of fenugreek alkaloids and.
Identification of the main component from the antimutagenic fractions. Antioxidant and antimutagenic potential of extracts of. Study of antimutagenic potential of phytoconstituents isolated from. This study was conducted to investigate the potential of turmeric extract.
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